γδ T cells recognize hMSH2 via both TCR and NKG2D Ectopically-expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human gammadelta T cells to induce innate anti-tumor/virus immunity
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چکیده
Background: Ectopically-expressed hMSH2 is tumor biomarker, however, the mechanism of its recognition is unclear. Results: hMSH2 interacted with both TCRγδ and NKG2D on Vδ2 T cells, resulting in Vδ2 T cell activation. Its expression was up-regulated by EBV infection. Conclusion: hMSH2 is a ligand for TCRγδ and NKG2D. Significance: Recognition of hMSH2 by γδ T cells induces innate anti-tumor/virus immunity.
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تاریخ انتشار 2012